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KMID : 0043320030260121042
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Archives of Pharmacal Research
2003 Volume.26 No. 12 p.1042 ~ p.1046
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Hypocholesterolemic Property of Yucca schidigera and Quillaja saponaria Extracts in Human Body
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Kim Sang-Woo
Park Sang-Kyu
Kang Sung-Il
Kang Han-Chul
Oh Han-Jin
Bae Chul-Young
Bae Dong-Ho
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Abstract
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This study was undertaken to observe the effects of the blend of partially purified Yucca schidigera and Quillaja saponaria extracts on cholesterol levels in the human’s blood and gastrointestinal functions, and to determine if a new cholesterol-lowering drug can be developed by the further purification of the extracts. Ultrafiltration and sequential diafiltration increased the amounts of steroidal saponin in aqueous yucca extract and terpenoid saponin in aqueous qullaja extract from 9.3% and 21.4% to 17.2% and 61.8%, respectively. Taking 0.9 mg of the blend (6:4, v:v) of the resulting filtrates a day for 4 weeks resulted in the decreases in total and LDL cholesterol levels in blood plasma of hyper-cholestrolemic patients with enhancement in gastrointestinal symptoms of patients.
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KEYWORD
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Yucca schidigera, Quillaja saponaria, Hypercholesterolemia, Saponin
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